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Phenergan Syrup should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depend on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. If you miss a dose, take it as soon as you remember it. However, you should never take a double dose. Inform your doctor if your symptoms do not improve within 7 days of treatment.